【摘要】 <正> 我们曾用阈下剂量的二亚硝基哌嗪作为起动剂,然后用硫酸镍作促癌剂,成功地诱发了大鼠鼻咽癌。为了解镍在实验大鼠体内,特别是在鼻咽部的分布,我们设计了本实验。 材料与方法 用25只雄性成年大鼠(体重约100g)分为实验组与对照组。 实验组:15只,除供给谷类与青饲料以外,每日从口腔内灌入1％硫酸镍溶液0.25ml,持续30天。停镍后第3天全部处死。更多还原

【Abstract】 Nasopharygeal carcinoma (NPC) had been succesfully induced in rats by subt-hreshold dose of dinitrosopiperazine (DNP) as an initiator and nickel sulfate as the promoter in our laboratory. Nickel content in organs or tissues in rats after administration of nickel sulfate solution was investigated by feeding 1% of NiSO4 solution 0.25ml P.O. daily for 30 days. All rats were sacrificed after 33 days.Thirteen organs and tissues,including mucosa of nasopharynx, were analyzed-for the nickel content by emission spectrum technique. Significant high level of nickel was found in trachea, nasopharynx, skull bone, esophagus, small intestine, spleen kidney and etc. The fact that higher nickel content in nasophatynx of the treated animals suggests the possibility of promoter effect of nickel on the deve lopment of NPC in rats, if the DNP,a chemical with high affinity to the naospha-rynx, was given as an initiator.更多还原