【摘要】 <正> 近几年来,国内应用活血化瘀药物治疗肾炎已见可喜苗头。据临床观察报告,在消除水肿、降低尿蛋白、改善肾功能方面,均有一定疗效。但其是否具有抗组织损伤作用,尚有待进一步证实。本文试从病理形态学角度对此予以探讨。材料与方法一、动物模型:本文以家兔 Masugi 肾炎作为病更多还原

【Abstract】 In order to investigate the effect of drugs for activating blood circulation and removing stasis on pathomorphologic lesions in glomerulonephritis,Ligustrazine and Activating Blood Circulation Injection(Salvia miltiorrhiza,Paeonia Lactiflora and Curcuma aromatica)were used to treat Masugi nephritis rabbits daily,together with urine protein assay.Renal biopsies were performed on the second day(heterologous phase)and the ninth day (autologous phase)after injecting nephrotoxic serum,and autopsy was done on the thirtieth day or thereabouts for immunofluorescent and pathomorphologic observation. The results showed that the proteinuria,the fibrin deposition in glomeruli and the pathomorphologic lesions were not so severe as those seen in the control animals.The crescent formation rate and the eosinophil infiltration rate were significantly lower than those of the control group(P<0.01).更多还原