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人体肺癌相关抗原的理化性质

PHYSICO-CHEMICAL PROPERTIES OF HUMAN LUNG CANCER ASSOCIATED ANTIGEN

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【作者】 袁秋琴李秀珍

【Author】 Yuan Qiu-qin

【机构】 上海市肿瘤研究所上海市肿瘤研究所

【摘要】 <正> 近年来我们从人体肺癌组织中提取可溶性抗原,兔疫动物所得之抗血清,经充分吸收后,以免疫酶标记及免疫荧光标记方法鉴定了该抗原与肺癌组织的相关性,在此实验研究的基础上,进一步提纯了抗原,并测定了其部分理化性质,现将实验结果报道如下:

【Abstract】 An antigen, isolated from human lung squamous cell carcinoma, was further purifica-ted. This antigen, with an isoelectric point pH4, migrated as anα12 globulin at pH8.6and was identified as a glycoprotein. It was demonstrated by SDS-polyacrylamide gelelectrophoresis as a single band in the molecular weight region of 43,000D. These physico-chemical properties coicided with those of lung cancer associated antigens reported by othergroups.

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