【摘要】 <正> 自1895年Rehn首次报道染料工人中膀胱癌高发以来,经过长期努力,联苯胺的致癌性早已肯定。1974年美国提出的14种对人致癌物和1979年IARC提出的25种对人致癌物均包括联苯胺,并明确其靶器官为膀胱。 我国制造联苯胺染料的历史可追溯到四更多还原

【Abstract】 A retrospective survey was conducted among workers exposed to benzidine in 5 dyestufffactories in Shanghai. The group observed consisted of 748 subjects working in benzidineworkshops for more than 6 months. According to their occupation, they can be dividedinto "pre-"and "post-process groups" consisting of 413 (354 men and 59 women) and 323(196 men and 127 women) subjects respectively. Another group was made of 556 (435 menand 121 women) persons not working in any benzidine workshops as controls. The durationof observation was calculationed from the day of entry into the benzidine workshops or thechemical factories to the end of 1982. A total of 62 cases of malignant tumor were reviewed. The results have shown that the morbidity and mortality of bladder cancer in theobservation group are significantly higher, and that the 15 bladder cancer cases, 14 malesand 1 female, all belong to the "pre-process groups". From the "pre-process group" it canbe seen that of bladder cancer is 3. 95%. Its standardized incidence morbidity and mortality,as well as the morbidity of all malignant tumors is 35.00. 31.25 and 1.78 respectively.These are all significantly higher than that for the Shanghai urban area (P<0.01).Furthermore, among this group, the highest morbidity occurs in those taking part in"material preparation" jobs, and the second highest is seen in these doing "synthsis" jobs, The total cigarette consumption on the "pre-process group", is more than that in the controlgroup (P<0. 05), and compared with the non-smokers of the control group, the relativerisk of bladder cancer in the smokers of the "pre-process group" (12.45, P<0.001)is higher than that in the non-smokers (4. 24, P>0.1). Analysis of 14 male bladder caseswas also made in regard to age at diagnosis, histological types, survival periods, inductiontime and the duration of exposure.更多还原