【摘要】 <正> 自然杀伤细胞(NK细胞)在没有抗原的刺激下,无需抗体和补体的参与,能在很短的时间内,直接杀伤瘤细胞。而抗体依赖性细胞介导的细胞毒作用(ADCC)必须在特异的抗体参与下,效应细胞才能对靶细胞起细胞毒作用,杀伤靶细胞。 NK和ADCC活性是重要的细胞免疫反应之一。对病毒感染、肿瘤、移植器官的排异反应和自身免疫性疾病的研究、诊治有着更多还原

【Abstract】 In the present study, we have introduced the method of determining natural killercell activity and antibody dependent cell-mediated cytotoxicity of human peripherallymphocytes. The normal values of healthy adults were NK, 20.76±8.77 and ADCC,62.54±12.13. In 24 cases of lung carcinoma, the NK was 13. 71 ±4. 34, the ADCC was45. 99±17. 18; in 14 cases of esophageal carcinoma, the NK was 8.07±5. 14, and theADCC was 39. 69±8. 68. The results in patients with lung and esophageal carcinoma show-ed relatively low level, especially in advanced cases, in whom NK and ADCC activitieswere significantly decreased. There were no statistical differnces between the data andpathologic cell type of lung and esophageal carcinoma. Clinical significance of NK andADCC in cancer diagnosis, evaluation of therapeutic effect and prognosis has been alsodiscussed.更多还原