【摘要】 <正> 阿霉素为治疗白血病及多种实体恶性肿瘤的有效药物。它抑制脱氧核糖核酸及/或核糖核酸合成。然而由于它对心肌具有毒性作用,甚至可导致心肌病,使其在临床的应用更多还原

【Abstract】 Adriamycine, an antitumor antibiotic, ranks among the best agents in the treatmentof leukemias and a variety of solid malignancies. However, because of its cardiotoxiceffects, the use of adriamycine is clinically limited. Cyclophosphamide, too, is found to becardiotoxic. In this study, the cardiotoxic effects of adriamycine (5mg/kg) and cyclophosphamide(200mg/kg), administered intravenously into rats, were studied under the electron micro-scope. Isolated rat heart, perfused in 60ml of recirculated perfusate with cyclophosphamide(100mg/kg) added to it, was also studied ultrastructurally. The heart specimens for studywere all taken uniformly from the papillary muscle of the left ventricle. In comparison with the ultrastructure of the normal heart muscle, there weresignificant changes in adriamycine and cyclophosphamide treated heart muscle, such as aggregation of nuclear protein in the nuclei of the muscle cells, separation of themitochondrian cristae and vacuolization, in the mitochondria. Besides the observation of the ultrastructural changes, the possible mechanism hasbeen discussed.更多还原