【摘要】 <正> 实验证明,血浆CAMP水平可反映β肾上腺素能神经功能状况,cGMP水平可反映胆碱能神经功能状况,对两者进行测定,可在一定程度上反映整体条件下植物神经的功能状态。本协作组曾用以大剂量山莨菪碱(654-2)为主的综合治疗,使感染性休克患者病死率明显降低。为阐明休克过程中神经体液因子如何调节把细胞的功能,从细胞水平探讨休克过程的某些病理生理机制以及654-2抗休克作用原理,设计了本课题的研究。材料和方法实验用成年健康杂种狗,14～26kg,共52条,分五组。第I组6条:生理盐水1.5ml/kg一次静注;第更多还原

【Abstract】 Plasma levels of cAMP and cGMP were measured in venous blood from anesthetized dogs before and after administration of E.coli endotoxin. Intravenous injection of endotoxin induced significant increase in plasma levels of cAMP and cGMP.Anisodamine reduced the plasma levels of cGMP in the control dogs and apparently prevented the rise in plasma levels of cGMP of the shocked dogs, of which the survival times were prolonged.Results suggest that the cholinergic nervous system might participate in the pathophysiology of endotoxin shock as well as the sympathetic nervous system. Some of the mechanism of anisodamine in endotoxinshocked dogs was discussed.更多还原