【摘要】 用不同剂量的日本血吸虫虫卵可溶性抗原(SEA)免疫正常小鼠,诱发其对虫卵的特异耐受性,结果显示小鼠经低剂量抗原连续皮下注射后可诱发出一定程度的低量免疫耐受性,使嗣后注入的日本血吸虫卵所引起的虫卵肉芽肿反应减弱,为利用SEA诱发宿主对虫卵肉芽肿应答的免疫耐受性研究提供了新线索。更多还原

【Abstract】 The results of the dynamics among the percentages of granulomas vs. eggs’ mean diameters in lung tissues in four groups of mice suggested that: 1. Low dosages of SEA 0.01-0. 1μg/g, q.d. × 14 by hypodermic injection may induce certain levels of low dose (or zone) tolerance in unsensitized mice; 2.There was a tendency of high dose tolerance, although it was not induced with the dosage used (2.5μg/g) by hypodermic injection; 3. Granuloma reactions in groups with low dosages of SEA were significantly higher at 24 hr after egg injection, but they became significantly lower from day 5 on. The reaction peak in the control group was on day 16 after egg injection, while in groups with low dosages of SEA was on day 10.Observations on the population dynamics of various types of cells of Schistosoma ja-ponicum egg granulomas showed that: 1. Lymphocytes, macrophages and fibroblasts often slightly increased within the first 3 days and lowered down between day 10 and day 16 after egg injection; 2. Eosinophils were higher at the first day and began to decline on day 4 and remained at a level lower than that in control group; 3. Populations of Neutrophils, plasma cells, giant cells and collagenous fibers were all roughly similar and in small numbers,更多还原