【摘要】 以接种艾氏腹水癌三天的昆明种雌性小鼠进行一次体内热化联合治疗,选用噻替派按每g体重0.08μg溶于生理盐水中,加温至43度后快速注入小鼠腹腔,并将小鼠置40度恒温箱内保温半小时。实验结果:腹水癌受到明显抑制,抑瘤率为46.6％、疗效高于单纯化疗及单纯热疗,与各对照组相比,体重下降及胸腺萎缩程度较轻,小鼠受到保护。热化联合治疗的效果优于单纯化疗及单纯热疗,可能与加热致使癌细胞膜“漏”,化疗药容易渗入细胞内发挥杀伤作用有关。更多还原

【Abstract】 Combined hyperthermia and-chemotherapy was" given to female mice of Kun Ming species, transplanted with Ehrlich-ascites cancer cells 3 days previously. For chemotherapy Thio-TEPA 0.08μg per gram body weight dissolved in normal saline and heated up to 43℃ was rapidly injected intraperitoneally. Then the mice were kept in 40℃ thermostat for 30 minutes. There was a significant inhibition of the growth of aseites cancer cells, the inhibition rate being 46.6％ and higher than that of either hyperthermia or chemotherapy alone. Decrease of the body wight and the thymic atrophy were less in the treated group than the control.更多还原