【摘要】 <正> 近年来硒和维生素E与大骨节病的关系引起国内研究者的注意,并从病因、防治、内外环境的调查研究方面作了不少工作,1979年李氏报导亚硒酸钠、维生素E治疗大骨节病效果显著。为进一步验证其效果及探讨硒和维生素E与大骨节病病因学关系,我们于1979年7月到1981年3月灵宝县病区对5—15岁154例病人用亚硒酸钠、维生素E进行20个月的X线和临床实验观察。同时对病区水、粮、发硒、更多还原

【Abstract】 This article chiefly deals with the observations on the therapeutic effects ofKaschin-Beck disease with sodium selenite and vitamin E,and the pathogenic re-lationship between selenium and Kaschin Beck disease. The results of the observa-tion of the 154 cases with Kaschin-Beck disease and the analysis of the water, sta-ple food grain (wheat,Indian corn,and black soga bean),blood-Se, hair-se andglutathione peroxidase in the endemic areas showed that the average amount ofhair-Se was lower than 200PPb,and the selenium in staple food grain and bloodwas lower than 0.02PPM.The contents of selenium in the things measured in theendemic areas were obviously lower than those in the non-endemic regins.Afteradministration of the drug,hair-Se content increased rapidly in the treated group,and two month later, it increased from 92ppb (before treatment) to 325ppb(treatment).But the hair-Se content of the controlled group was at the level of theendemic areas. The activity of glutathions peroxidase, the recovery of the pathologi-cal changes of the metaphyses and the clinical improvement were statistically sign-ificant between the two groups.It shows that the endemic regions are under thecondition of low selenium, the human body is in low selenium nutritive state, andselenium and vitamin E have a great effect for the recovery from the metaphysesand the clinical improvement of the disease.It also indicates that selenium andvitamin E have a close relationship with the pathogenesis of Kaschin Beck disease.更多还原