【摘要】 <正> 1979年我国首次报告亚硒酸钠、维生素E(VE)治疗大骨节病取得显著效果。同年7月至1981年3月河南省卫生防疫站、中国科学院地理研究所和灵宝县防疫站联合在河南又重复了该项实验并作了动态观察。同时对水、粮、发中硒及血中谷胱甘肽过氧化物酶(GSH-px)、VE含量作了测定。认为骨质的修复是补充硒及VE的结果,并表明大骨节病区为低硒地区。更多还原

【Abstract】 The activities of blood glutathione peroxidase (GSH-px ) and the contents ofvitamine E (VE), lipid peroxide (TBA) and free fatty acid (FFA) in childrenwere determined in the Kaschin Beck disease effected areas. These results showedthat the activities of blood GSH px and the levels of VE were lower than thoseof children in the non effected areas (P<0.001).But the levels of blood TBA andFFA were higher than those of children in the non effected areas (P<0.001). These changes suggest that the Se dificient states of the children’ body mig-ht induce the disorder of lipid metabolism, which provides leads for furtherstudying pathogenesis of the disease.更多还原