【摘要】 <正> 对氨基水杨酸钠(PAS-Na)作为抗结核药应用已有多年,虽然毒性较小,但连续服用量较大,且本品稳定性差,PAS-Na的降解反应是先脱羧,后氧化、聚合,因此产生不同程度的颜色。为了确保用药安全与有效,本文拟对其稳定性及影响色泽变化的各种因素进行探讨。更多还原

【Abstract】 Experiment was conducted to determine the factors which were important in influencing the stability of Na-PAS in the solid state. Typical curves were given which indicate the influence of temperature, moisture and ere on the coloring reaction. Relationship between the character of water content and the coloring of Na-PAS was studied. It was found that if water was attached in a free state, coloration occurred very significantly.更多还原