【摘要】 利凡诺为一有效的中期引产药,但对其作用机制,迄无定论。本实验采用放射免疫测定技术,观察了10例孕妇在给利凡诺前、给药后10～15小时、宫缩开始时和流产前羊水中前列腺素水平的动态变化,其中PGE分别为213±54,553±138,968±243和1475±869（pg/ml）;PGF_2a分别为369±104,392±167,1582±548和6006±2131（pg/ml）。结果表明,利凡诺引产的发动和进展,可能与内源性前列腺素的合成和释放增加有关。更多还原

【Abstract】 In order to investigate the kinetic changes of endogenous prostaglandin （PG） concentrations during the process of abortion induced by intra-amniotic injection of rivanoi, serial samples of amniotic fluid were taken before and after rivanol administration in 10 mid-term pregnant women. The PG concentrations were determined by radioimmunoassay. Amniotic fluid PGE increased from a pre-rivanol level Of 213±54 to 553±138 （pg/ml）, ten to fifteen hours after administration, 968±243 （pg/ml） at commencement of uterine contraction and 1475±869 （pg/ml） before abortion with cervix diameter of 3～4 cm; the corresponding values for PGF_2α were 369±104, 392±167, 1582±548 and 6.006±2131 （pg/ml）.The results indicate that the PGE and PGF_2α levels in the amniotic fluid increased gradually in the course of rivanol-induced abortion, and the increase of PGE level was initiated long before the commencement of urerine contraction. It is, therefore, concluded that the increase of PG level in the amniotic fluid may be responsible for the initiation and progress of rivanol-induced abortion.更多还原