【摘要】 醇甲为五味子仁乙醇提取物中主要有效成分之一。腹腔注射明显延长小鼠戊巴比妥钠及巴比妥钠的睡眠时间,减少小鼠自主活动,并加强利血平及戊巴妥钠对自主活动的抑制作用,对抗咖啡因、苯丙胺对自主活动的兴奋作用。醇甲对抗MES、戊四唑、菸碱及北美黄连碱的强直性惊厥,抑制小鼠由电刺激或长期单居引起的激怒行为,对大鼠回避性条件反射及二级条件反射有选择性抑制作用,大剂量使大鼠产生木僵,该木僵可被脑室注射DA所对抗。从实验结果看来,醇甲有广泛中枢抑制作用,并且有安定药的作用特点。更多还原

【Abstract】 Schizandrol A is one of the active constituents isolated from the ethanol extract of the dried fruit of Schizandra chinensis Baill（Fructus schizandras）. Intraperitoneal injection of a dose of 1/10 LD₅₀ of schizandrol A in mice prolonged the sleeping time induced by pentobarbital or barbital. In doses of 1/50 LD₅₀, schizandrol A decreased the mice spontaneous motor activity （SMA）. Schizandrol A also enhanced the inhibiting effects of chlorpromazine, reserpine and pentobarbital, and antagonisted the stimulating effects of amphetamine and coffeine on SMA in mice. The ID_50s of schizandrol A on tonic convulsion induced by electric shock （MES）, metrazol, nicotine and hydrastine were 55, 51, 58, and 82 mg/Kg respectively, and those on foot shock aggression and isolated aggression in mice were 99 mg/Kg and 35 mg/Kg. The specific avoidance-blocking activity produced by neuroleptics was also produced by schizandrol A in rats. When schizandrol A was given at higher doses to rats, catalepsy was observed which could be prevented by prior intraventricular injection of dopamine. These experimental results indicate that schizandrol A posseses extensive inhibiting effects on the CNS which is charateristic for neuroleptics.更多还原