【摘要】 用电位滴定法、分光光度法及磁化学法研究了作为铁剂注射液处方基础之一的铁(Ⅲ)—山梨醇—柠檬酸系统,以阐明山梨醇对铁离子水解沉淀的抑制作用机理。结果表明,在防止铁离子水解聚合及沉淀方面,柠檬酸起络合掩蔽作用,而山梨醇不与铁离子配位结合但能使聚合作用停止在形成单核或二核物种阶段。这一作用有利于形成稳定的二核柠檬酸络合物,因而使制剂更为稳定。更多还原

【Abstract】 By means of potentiometric, spectrophotometric and magnetochemical methods, the sorbitol-citric acid-Fe (Ⅲ) system was studied to clarify the mechanism of action of sorbitol on the inhibition of hydrolytic precipitation of ferric ion. The experimental results show that sorbitol did not coordinate with ferric ion but stopped the hydrolytic process at the oligomerie stage, in which, mono—or bi-nuclear species were present. This effect is in’ favour of the formation of stable binuclear complexes of citric acid and makes the preparations more stable.更多还原