【摘要】 本文主要讨论了化学药物不同给药时间的致畸效应。根据我们的实验,初步认为:对妊娠大鼠一次给药,以妊娠的第9、10或11天为宜,连续给药以9～12天为宜;如果必需进行整个妊娠期给药,可考虑在妊娠的6～15天连续给药。更多还原

【Abstract】 This experiment was conducted with virgin wistar female rats. The body weight of the female rats was 195～339 g, that of the males was 285～373 g. The males and females were allowed to mate over-night at a ratio of 3:1. Then the pregnant rats were divided into groups (see table 1 and 2). Bis-A-TDA was given orally on various days.The rats were killed on day-20 of gestation so as to count the number of corpora lutea, implantation sites and live fetuses. The living fetuses were removed, weighed, inspected for gross abnormalities and sexes; the internaland skeletal malformations Of live fetuses were examined by Wilson’s method.The following results wereobtained:1. If one dose is given, the most suitable time is to give the drug on the 9 th,10th or 11th day of gestation;2. Continued treatment is appropriate from the 9 th to the 12 th day of gestation;3. The drug may be given for 6～15 days if necessary during whole period of gestation.更多还原