【摘要】 本文报告广东地区0—54岁白血病病人Hp~1频率显著高于正常人,其相对危险率为1.9,提示这一地区Hp~1基因与白血病发生有关。急粒和急淋组Hp~1频率显著高于正常人,慢粒组则与正常人无显著差异。化疗后的急拉和急淋组Hp2-2型和Hp2-1型Hp平均含量较化疗前显著降低,Hp1-1型则降低不显著;慢粒组三类Hp平均含量化疗前后无明显变化。提示Hp~1基因可能与急性白血病发生有关。具有Hp纯合子或杂合子正常母亲的白血病子女中,纯合子与杂合子的比例符合预期比例,提示在白血病病人家庭中Hp的遗传方式无异常。还观察到,肝癌中Hp~1频率亦显著增高,提示Hp~1基因除与白血病有关外,还可能与其他某些肿瘤的发生有关。更多还原

【Abstract】 Haptoglobin (Hp) phenotypes were determined in 221 leukemia patients and 969 healthy controls in Guangdong.An increased frequency of Hp1 allele in patients (age 0-54) was found,and the relative risk ratio of individuals with Hp 1-1 suffered from leukemia is 1.9,suggesting that Hp1 allele may be related to leukemia in this area.An increased frequency of Hp1 allele was revealed in 83 acute granulocytic leukemia (AGL) patients and 57 acute lymphocytic leukemia (ALL) patients,but not in 59 chronic granulocytic leukemia (CGL) patients.The levels of serum Hp tested after chemotherapy were more significantly decreased in AGL and ALL with Hp 2-2 or Hp 2-1 than before,but not in Hp 1-1.An unsignificantfy changed level of serum Hp was observed in CGL with Hp 2-2 or Hp 2-1 or Hp 1-1 before and after chemotherapy.The results suggested a relationship between Hp1 allele and acute leukemia in this area.Hp phenotypes of 45 healthy mothers and their leukemic children were determined.The frequencies of homozygotes and hetrozygotes given birth by homozygous or hetrozygous mothers were distributed essentially as expected.In addition,an increased frequency of Hp1 allele was found in 159 heptocarcinoma patients,suggesting that Hp1 allele may be also related to some other tumors besides leukemia.更多还原