【摘要】 <正> 基底细胞痣综合征(basal nevus syndrome)为一种遗传病,以皮肤多发性色素痣恶变成基底细胞癌,并伴有下颌囊肿、骨骼畸形和神经系统疾病等综合病症为特征。其遗传学研究资料尚少,国内外还未见应用G显带染色体和姐妹染色单体互换(SCE)的报道。1979年我院附属医院发现一例基底细胞癌患者。1981年我们对患者进行家系调更多还原

【Abstract】 This paper presents a systematic genetic study of basal cell nevus syndrome (BCNS) in one family.The results shew that this syndrome belongs to a dominant heredity of the autosomes.We have not found any numerical and structural abnormalities in routinely-treated and G-banding chromosomes.The SCE frequency in an individual with malignant change,however,is distinctly higher than a normal and unaffected one,which can be used as an important predictor in identifying malignant change of pigmental nevi.Consequently,a genetic study of BCNS has important significance in genetic counselling,clinical diagnosis and treatment,and prophylaxis.更多还原