【摘要】 本文用不能躲避的间歇脚底电刺激引起大鼠应激,用电刺激鼠尾-嘶叫法测定镇痛效应,研究下丘脑弓状核(脑内β-内啡肽能神经元胞体集中的部位)、中缝背核(脑内5-羟色胺能神经元胞体主要集中的部位之一)和蓝斑(脑内去甲肾上腺素能神经元胞体主要集中的部位之一)与应激镇痛的关系。 用新生大鼠腹腔注射谷氨酸-钠的方法损毁弓状核后,用海人酸和电解两种方法损毁中缝背核或蓝斑后,应激镇痛效应均明显减弱。由于谷氨酸-钠和海人酸只选择性地损毁神经元胞体,故认为脑内的β-内啡肽能神经元、5-羟色胺能神经元和去甲肾上腺素能神经元均参与应激的行为镇痛。更多还原

【Abstract】 It is well known that the β-endorphin-containing neurons,serotonin-containing neurons and noradrenaline-containing neurons are concentrated inhypothalamic arcuate nucleus,dorsal raphe nucleus and locus coeruleusrespectively.In this study the effects of lesion of these three nuclei onstress-induced analgesia were investigated in rats.Stress was produced byinescapable intermittent footshock,and the analgesic effect was measuredby tail stimulation-vocalization test. After monosodium glutamate-induced arcuate nuclear lesion and kainicacid-induced lesion or electrolytic lesion of dorsal raphe nucleus and locuscoeruleus,the analgesic effect of footshock stress was decreased significantly.It is suggested that β-endorphin-,serotonin-and noradrenaline-containingneurons might play an important role in stress-induced analgesia.更多还原