【摘要】 <正> 肝脏是多种凝血因子的合成场所,重症肝病时因凝血因子减少可发生止血障碍。与此相反,国内外文献均报告肝病时因子Ⅷ却是增加的。因子Ⅷ是一种蛋白复合体,其中能被异种抗血清所沉淀的因子Ⅷ相关抗原更多还原

【Abstract】 Factor Ⅷ related antigen (ⅧR:Ag) was measured in 28 healthy subjects and 113 patients with hepatobiliary diseases. A comparison of these results with other lab aratory data available for diagnosis showed that the ⅧR:Ag value had statistically significant difference between healthy subjects and all groups of patients, and between groups of patients.Consequently, it was suggested that the measurement of ⅧR:Ag could be used to detect the existence of hepatobiliary diseases and aid to identify the nature of the diseases, especially the primary carcinoma of the liver. There was no correlation be tween the ⅧR:Ag value and the laboratory findings of liver function. Thus ⅧR: Ag does not reflect the parenchymal impairment of the liver. In hepatobiliary disease elevated ⅧR:Ag value is due to increased release by the impaired vascular endothe lium of the liver and decreased clearance by the liver.更多还原