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酶谱诊断心肌梗塞特异性的探讨

The Specificity of Enzyme spectrum in the Diagnosis of Acute Myocardial Infarction

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【作者】 戴闺柱; 周本财; 郭和平; 刘红进;

【Author】 Dai Guizhu, Zhou Bencai, Guo Hepin, Liu Hongjin The Cardiovascular Disease Institute, Wuhan Medical College,wuhan

【机构】 武汉医学院心血管疾病研究所; 武汉医学院心血管疾病研究所;

【摘要】 <正> 血清酶活性变化与典型胸痛病史、心电图演变并列为诊断心肌梗塞的条件之一。特别是在心电图图象不典型或受干扰时(左束支传导阻滞、预激综合征等),有持续胸痛、连续的ST段压低及(或)T波倒置(超过24小时),但未发生Q波时,欲区别为不稳定性心绞痛抑或确已发生了非透壁性心肌梗塞,

【Abstract】 The enzyme spectrum-CPK, ASAT, LDH, ALAT-was investigated in 26 cases of acute myocardial infarction (AMI) and 72 cases of non-infarct patients with heart failure, dysrrhythmia etc. Within the is ~4th days after the attack cf AMI,the sensitivity of CPK, ASAT and LDH is 100%. Estimating ASAT and ALAT coincidentally could be helpful in. distinguishing whether the ASAT activity is cf cardiac or of hepatic origin. The false positive percentage of the single enzyme elevation in the 72 cases of noninfarct patients were: CPK 20.3%, ASAT 17.4% and LDH 16.4% respectively while the percentage of simultaneous elevation of all these three enzyme activities was only 4.6 %, statistically lower than that of the single enzyme and is comparable to the specificity of the isoenzymese. Since the isoenzyme assay is not widely used so far, therefore, the observation of enzyme spectrum should be emphasized, so as to improve the diagnostic specificity.

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