【摘要】 <正> 已知奇数碳脂酸能和偶数碳脂酸一样在体内进行β-氧化,不同的是奇数碳脂酸氧化后的终末三碳残基-丙酰CoA是生糖的。某些研究工作者曾观察过奇数碳脂酸在动物体内储存和动员情况,并从不同角度研究了体内储存一定量奇数碳脂酸的更多还原

【Abstract】 Sixty-four male rats were divided into two groups. Each group was fed on the diet containing, as a percentage of dietary, energy. 20% protein, 50% carbonhydrate, 30% fat. The source of fat was undccanoin-onprin (1:1) for the experimental rats, and soybean oil for the controls. At the end of the 8th-week, each sixteen rats of both groups were killed after 4, 24, 48.72 hours of starvation respectively.The preliminary results were obtained as follows:1.At the 24th hour of fasting, the plasma glucose and immunoreactive insulin of the rats enriched with OMFA were significantly higher than that of the control rats (P<0.001 and P<0.01); Liver glycogen decreased dramatically after 4 hours of fasting, but the experimental rats exhibited a little higher level in comparision with the controls.2.Plasma FFA concentration of both groups was significantly elevated and reached the peak value at the 24th hour of fasting. However, the composition of fatty acid in adipose tissue kept consistent in both groups.3.During 4-24 hours of fasting, the changes in cAMP level in liver, perirenal adipose tissue and pancreas were corresponding with the changes in liver glucogen, plasma FFA, blood glucose and circular insulin at the same time.It is concluded that during fasting, OMFA could be mobilized as well as endogenous even-numbered fatty acids, and showed unique metabolic effect on glucose ho-meostasis because its terminal three-carbon residue arising from 6-oxidation of these acids was glucogenic.更多还原