【摘要】 <正> 镉、汞、铅、砷、铬等有毒金属是较为重要的环境污染物,关于它们进入机体后对哺乳动物肝微粒体混合功能氧化酶系影响的研究,国外从七十年代初已经开始,例如已有人证明镉、铅的无机化合物和甲基汞是大鼠肝微粒体混合功能氧化酶的抑制更多还原

【Abstract】 In this study the authors studied the acute effects of 5 toxic metals (cadmium, mercury, lead, chromium and arsenic) and a lead-zinc ore on the microsomal mixed function oxidase system of the male rat. The results showed that the liver microsomal mixed function oxidase activity was inhibited 72 hrs following a single dose of cadmium acetate (2.4mg/kg ip) and 24 hrs following a single dose of mercuric chloride (2.0mg/kg ip), lead acetate (100 mg/kg ip) or lead-zinc ore (1100 mg/kg ip), respectively. Single dose of sodium chromate (17mg/kg ip) or sodium arsenite (4.0mg /kg ip) did not exhibit any effect on the microsomal mixed function oxidase activity 24 hrs following the treatment. The results of in vitro experiments showed that cadmium, lead, mercury, and chromium could inhibit the activity of hepatic microsomal aniline hydroxylase and decrease the concentration of hepatic microsomal cytochrome p-450 directly. The mechanisms by which the activity of hepatic microsomal mixed function oxidase were depressed by cadmium, lead, and chromium were tentatively discussed.更多还原