【摘要】 <正> 在淋巴网状组织包括淋巴结和结外病变的日常活体组织检验标本中,有时可见到病程较长的滤泡型或弥漫型反应性过增生(reactive hyperplasia)发展成为恶性淋巴瘤的病例。因此,令人产生这种想法,即非特异性反应性过增生可发展成为恶性淋巴瘤发生更多还原

【Abstract】 An unusual case of malignant lymphoma is reported. The biopsy specimens of the patient’s cervical lymph nodes were proved 2 times to be follicular reactive hyperplasia. The enlarged lymph nodes almost disappeared, after treatment with anti-inflammatory drugs. However, 14 months after disappearance of the enlarged cervical lymph nodes, an enlarged submendibular lymph node measured 3.5×2×2 cm was found and excised. At its center, a tumor measured 2.7×1.8 cm was found. Microscopically, the tumor tissue was proved to be a typical malignant lymphoma and was surrounded by follicular reactive hyperplastic tissue. Furthermore, transitional pattern was found between the tumor and follicular hyperplastic tissues. This led us to consider that frequent recurrence of follicular reactive hyperplasia of lymph node may develop into malignant lymphoma and that the constituent cells of the reactive follicular germinal center transform from polymorphous into monomorphous may be regarded as the prodromal sign of malignant change.更多还原