【摘要】 本文对13例日本血吸虫病患者(其中晚血7例,慢血6例)和4名正常人于口服吡喹酮后作药物代谢动力学观察,结果表明,患者服吡喹酮后,吸收慢、排泄差、血液中药浓度明显增高,并维持较长时间;晚血患者的血药浓度更高。正常人则吸收迅速、排泄快。并提出总剂量为45mg/kg体重(目前使用的总剂量为60mg/kg体重)的2天疗法方案。更多还原

【Abstract】 The pharmacokinetics of praziquantel was studied with high performance liquid chromatographic (HPLC) method in 6 chronic and 7 late cases of schistosomiasis japonica and 4 normal individuals. It was found that excretion of the drug was slower in patients than in normal individuals so that there was a high and long lasting plasma concentration of the drug in the patients, and in late cases the blood concentration was even higher. The level of blood concentration was found to be related to the incidence of side effects. With such findings, the authors suggest that the current total dosage of 60mg/kg body weight in two days could be reduced to that of 45mg/kg.更多还原