【摘要】 成年大鼠肝大部(68％)切除后,肝细胞摄取氚化脱氧胸苷(~3H-dT)的核标记指数和分裂指数分别于术后24小时和36小时达高峰。高峰后24小时内下降较快,随后继续缓慢下降。肝细胞核标记指数和分裂指数的动态曲线十分相似,二者之间呈现明显的相关。正常成年大鼠于抽取一定量血液后予以注入等量生理盐水,发现其肝细胞分裂指数与血液稀释度呈正比关系。据此,讨论了肝大部切除后肝细胞的增殖规律性及其与体液因子(肝抑素)调节作用的关系。更多还原

【Abstract】 After partial hepateotomy (68%) of adult rats, the 3H-dT labeled rate and mito tic index of hepatocy tes reached a high peak at the 24 th and 36 th hour respectively-Then, it declined rapidly within the next twenty-four hours. After that the reduced changes became slow. The kinetic curves of labeled rate and mitotio index were very similar, showing a definite regular change between them.The blood of normal adult rats was drawn from artery, and the rats were perfu-eod immediately with equal part of physiological saline. The results indicated that the smittic index of hepatocytes was shown to be directly proportional to the degree of lbood dilution. The liver regeneration and its relation with control function of humoral factors (hepatic chalone) for hepatocytic proliferation was discussed.更多还原