【摘要】 用乌头碱诱发小鼠心律失常的模型,观察毒毛旋花子甙K(毒K)和冰凉花总甙(又称新福甙)分别与心得安、苯妥英钠、利多卡因、溴苄乙铵、双异丙吡胺和常咯啉联用后的相互作用。毒K具有对抗乌头碱性心律失常的作用,且能增强常咯啉或心得安的抗心律失常作用。毒K与利多卡因、苯妥英钠或溴苄乙铵联用呈相加作用。单用冰凉花总甙未见有抗心律失常作用,但却能增强双异丙吡胺的抗心律失常作用。双异丙吡胺与常咯啉联用时呈相加作用。更多还原

【Abstract】 By rapid screening method of antiarrhythmic drugs in mice, the synergistic effect of K-strophanthin or Adoniside and other known antiarrhythmic drugs as well as the antiarrhythmic interrelationship between disopyramide and changrolin were observed. The results suggested that K-strophanthin not only possessed an antiarrhythmic action, but also potentiated the antiarrhythmic action of changrolin and propranolol. Furthermore, when K-strophanthin was used in combination with lidocaine, phenytoin sodium or bretylium, the antiarrhythmic action appeared to be additive. Although Adoniside was unable to prolong the latent period of cardiac arrhythmia, yet it could potentiate the antiarrhythmic action of disopyramide. The antiarrhythmic actions of disopyramide and changrolia were also shown to be additive.更多还原