【摘要】 本文介绍鞣化羊红细胞电泳缓慢百分率方法检测人骨胳肌提取AchR粗制品对周围血淋巴细胞的免疫反应。共测定正常人40例,重症肌无力76例,散发性脑炎20例,肌营养不良症9例,多发性肌炎7例,癫痫5例,运动神经元疾病3例,中风后遗症2例。结果提示,重症肌无力总阳性率81.6％;阳性率与病程有关;皮质类固醇激素治疗抑制阳性反应。作者认为,重症肌无力周围血液中存在AchR致敏的淋巴细胞,这些细胞能引起或加重肌无力症状;皮质类固醇激素抑制T-细胞的细胞免疫反应而改善症状。最后认为,鞣化羊红细胞电泳检测AchR体外对淋巴细胞的免疫反应,为重症肌无力的诊断和治疗提供了参数。更多还原

【Abstract】 This paper introduced the use of tanned sheep erythrocyte electrophoresis mobility (TEEM) test in measuring peripheral lymphocytes immune response to crude AchE derived from human being amputated legs muscles. The total number of cases tested included 40 normal subjects, 76 myasthenia gravis, 20 sporadic viral encephalitis, 9 muscular dystrophy, 7 polymyositis, 3 motor neuron diseases, 5 epilepsia and 2 sequential cases of stoke. Results indicated: no response in normal controls, and a positive rate of 81.6% in myasthenia gravis. The positive rate was relavent to the duration of disease. The shorter the duration of the disease, the higher the positive rate would be. It was also found that the positive rate to AchR might be inhibited by steroid given. The writers suggested that some peripheral lymphocytes sensitilized to AchR induce or accelerate the myasthenic symptoms, that myasthenic symptoms are improved by steroid treatment because of cellular immunity of T-lymphocytes inhibited. Finnally it is considered that TEEM test with lymphocytes stimulated by AchR in vitro may provide auseful parameter for the diagnosis and treatment of myasthenia gravis.更多还原