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家兔肝部分切除后游离脯氨酸代谢变化

CONCENTRATION OF FREE PROLINE FOLLOWING PARTIAL HEPATECTOMY IN RABBITS

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【摘要】 本实验研究了家兔肝部分切除后游离脯氨酸代谢的变化。实验结果表明:肝部分切除后,外周血液游离脯氨酸浓度显著升高有其特有的变化规律,可能作为评价肝大部分切除后余肝再生状态的一个有用指标。

【Abstract】 The concentration of free proline followingpartial hepatectomy in rabbits has been studied.Concentration of free proline in serum and liverhomogenate was significantly increased afterpartial hepatectomy,but returned to almostpreoperative level when the liver was restored to92% of its preoperative weight.The resultsobtained from normal and sham-operation groupwere compared with those of the hepatectomizedgroup.It is evident that the significant increaseof free proline in serum after partial hepatectomyis a relatively specific change of hepatectomy.Measurement of the change of free proline inperipheral blood is probably useful in the evalua-tion of the state of regenerating liver remnantafter partial hepatectomy.

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