【摘要】 本组病例男性占75.5%,临床主要表现有吃奶少、哭声小、反应下降、面色灰白、体温异常(多呈微热,占59.2%)等。分叶核粒细胞绝对值大于7,000占75.5%,白细胞总数及分叶均升高者44.9%。脐炎为主要感染途径,占55.1%。抗生素敏感过半数的有先锋、白、新生、新、庆大霉素及多粘菌素等。凝固酶阴性抗药性大于阳性(P<0.01)。病死率为12.2%。鉴于国内尚无诊断标准,本文提出:凡具备主要临床表现及下述一项即可诊断。(1)血培养2次以上阳性;(2)血培养1次阳性,但在病灶中培养出相同菌株;(3)血培养1次阳性,但临床症状及周围血象改变明显,用敏感抗生素有效。更多还原

【Abstract】 Fourty-nine cases of neonatal sepsis due to staphylococcus albus were reported. Out of 49 cases 37 were males. The chief clinical features were poor feeding, weak crying, apathy, pallor and mild fever (59.2%). Thirty-seven of the 49 cases(75.5%) had an absolute neutrophil count over 7000/mm~3 and 17 of the 37 cases(46.9% )had both elevated white blood count and neutrophil percentage. Infection originated from omphalitis in more than half of the cases (55.1%). There were 3 cases complicated with meningitis, 1 NEC and 1 toxic hepatitis. Effective antibiotics were cephalothinum, leucomycin, novobiocin, neomycin, gentamycin and polymycin. The coagulase-negative staphylococcus is more resistant to antibiotics than the coagulase-positive (P<0.01). The mortality was 12.2%.In recent years, staphylococcus albus seems to be an important organism causing the neonatal sepsis in this country. We considered that a diagnosis of neonatal sepsis clue to staphylococcus albus can be made by one of the following criteria: (1)isolation of the organism from blood cultures for 2 times; (2) isolation of the organism from the blood culture for 1 time and obtaining the same organism in another focus; (3) isolation of the organism from the blood culture for 1 time and having obvious changes of peripheral white blood cell count and clinical manifestations with a good response to the related antibiotics.更多还原