【摘要】 本文报告小白鼠腹腔注射藤黄针剂的急性毒性试验:LD₅₀为33mg/Kg（可信限26～40）。亚急性毒性试验:大白鼠每日一次腹腔或皮下注射藤黄针剂2.5、5、10、15mg/Kg,持续一个月,呈现心肌浊肿、肾浊肿、肝细胞变性、腹膜炎或皮下硬结以及肝点状坏死等毒性病变。并对毒性病变的性质进行了讨论。更多还原

【Abstract】 Injecrio Gambogiae was prepared from Gambogia which was the dry resin secreted by Garcinia morella Desv. The acute LD₅₀ of Injeetio Gambogiae in mice was 33mg/kg ip （confidence interval 26—40）. Injeetio Gambogiae was given 15, 10, 5, 2.5mg/kg ip or H daily to 54 rats for 1 month. The major target organs of toxicities were heart, liver, kidneys, lungs and peritonium（or subcutaneous tissues）. Peritonities （or subcutaneous nodules）and focal necrosis of liver were directly induced by Injectio Gambogiae.更多还原