【摘要】 合成和鉴定了十六种新的含卤根的氨基酸乙酯的二价铂配合物。其中八种含碘配合物[PtA₂I₂]（A=DL-α-AlaOEt,L-α-AlaOEt,DL-α-PheOEt,L-α-PheOEt,DL-α-AspOEt,L-α-AspOEt,DL-α-SerOEt）和[PtAI₂]（A=L-α-LysOEt）以及部分含氯配合物[PtA₂Cl₂]（A=DL-α-PheOEt,DL-α-ASpOEt,L-α-AspOEt）和（DL-α-PheHOEt）₂[PtCl₄]由K₂[PtX₄]（X=I^-,Cl^-）与相应酯在水中作用而得。易水解的其它含氯氨基酸乙酯配合物[PtA₂Cl₂]（A=DL-α-AlaOEt,L-α-AlaOEt,L-α-pheOEt,DL-α-serOEt）通过相应的含碘配合物[PtA₂I₂]与AgCl在非水体系（丙酮）中交换而成。摩尔电导率表明,除（DL-α-pheHOEt）₂[PtCl₄]外,所得配合物均为电中性。分子偶极矩测定和改良的硫脲反应确定了七种含碘配合物:三种含氯配合物[Pt（L-α-AlaOEt）₂Cl₂],[Pt（DL-α-AlaOEt）₂Cl₂]和[Pt（DL-α-SerOEt）₂Cl₂]为顺式构型,其余四种为反式构型的含氯苯丙氨酸乙酯或含氯天冬氨酸乙酯配合物。对决定配合物构型的主要因素进行了讨论。更多还原

【Abstract】 Sixteen new halogenoethylaminoacidato Pt（II） complexes were synthesized and characterized,of which eightiodocomplexes [PtA₂I₂] （A=DL-α-AlaOEt, L-α-AiaOEt.DL-α-PheOEt, L-α-PheOEt, DI-α-AspOEt, L-α-AspOEt,DL-α-SerOEt and L-α-Lys OEt）, four chloro compounds [PtA₂Cl₂] （A=DL-α-PheOEt, DL-a-AspOEt, L-α-AspOEt） and （DL-α-PheHOEt）₂[PtO14] were obtained by reaction of K₂ [PtX₄] （X=1,Cl ）with the corresponding ethylaminoacidates in water.The other chloroethylamincacidato Pt （II）complexes [PtA₂Cl₂] （A=DL-α-AlaOEt, L-α-AlaOEt, L-α-PheOEt, DL-α-SerOEt） were synthesized in acetone by exchange reaction of the corresponding iodo complexes with AgCl in order to avoid hydrolysis of the ethyl aminoacidates.Molar conductivity determination showed that all the Pt（II） complexes obtained were neutral molecules with the exception of （DL-a-PheHOEt）₂ [PtCl₄] which existed as an anion. As shown by dipole. moment determination and modified thiourea reaction,iodo complexes 1～7 and some of the chloro complexes [PtA₂Cl₂] （A=DL-α-AlaOEt.D-α-AlaOEt, DL-α-SerOEt）were of cis-configuration and the other chloro complexes were of trans-configuration.更多还原