【摘要】 本实验测定了接受胆碱酯酶抑制剂新斯的明注射的小鼠股骨骨髓乙酰胆碱的浓度,并进行了股骨骨髓粒系定向造血干细胞测定和有核细胞及周围血白细胞计数。结果表明,小鼠骨髓乙酰胆碱浓度的升高对粒系细胞生成无明显影响,故认为小鼠体内乙酰胆碱可能并不参与骨髓粒系定向造血干细胞增殖分化的调节。更多还原

【Abstract】 The study was made on the effect of endogenous acetylcholine(Ach)ongranulopoietic stem cells(CFU-Cs)in the bone marrow of mouse received injectionof neostigmine,a the cholinesterase inhibitor.Bioassay showed considerable rise ofAch concentration of mouse bone marrow,howerer,the number of CFU-Cs andgranulocytes in femoral bone marrow as well as the granulocyte count in peripheralblood did not change apparantly.It is thus deduced that endogenous Ach mightdo not take part in the regulation of proliferation and differentiation of CFU-Csof mouse bone marrow.更多还原