【摘要】 本文用放射免疫分析法和蛋白竞争结合分析法研究抗休克中药枳实的有效成分对动物血浆和心肌环核苷酸含量的影响。实验结果证明对羟福林使小白鼠血浆和心肌的 cGMP 含量增加,N-甲基酪胺使大鼠血浆 cAMP 含量增加。更多还原

【Abstract】 N-methyltyramine and synephrine are effective components of Zhishi,anantishock drug of Chinese medicine.We have had demonstrated a significantincrease in plasma cGMP and myocardial cAMP and cGMP level after the admin-istration of N-methyltyramine.The supplemental data provided by the recent ex-periments showed that the cGMP level in plasma and myocardium increased afterthe administration of synephrine,while the cAMP level in plasma increased afterN-methyltyramine administration.The evidence obtained confirms the earlier suggestion that cAMP and cGMPare the mediators of the cardiovascular action of N-methyltyramine and also pointsto the cGMP as the mediator of the action of synephrine.更多还原