【摘要】 为探讨红细胞溶血的机理,研究减少贮存红细胞溶血的方法,我们从红细胞膜结构功能的角度出发,设想在全血中添加一种与磷脂结构及磷脂代谢有关的物质——胞嘧啶核苷二磷酸胆碱(CDP-胆碱),观察它是否能对溶血产生影响,并进一步研究其作用机理.结果证明:CDP-胆碱的存在可显著减少贮存过程中红细胞的溶血,并可增强贮存红细胞对保温及低渗的抵抗能力.此事实为研究红细胞溶血提供了一条新的途径,而且也提示了CDP-胆碱在血液保存中实际应用的可能性.更多还原

【Abstract】 In order to investigate the mechanism of hemolysis and find out a method to prevent hemolysis of stored erythrocytes, it is proposed to see whether the addition of cytidine diphosphate choline (CDP-choline), which is related to the structure and metabolism of phospholipid, to whole blood, would influence the hemolysis of red cells, and thus serve to make a further research into the mechanism of hemolysis. It is demonstrated that with the supplementation of ODP-choline, the hemolysis of stored erythrocytes could be reduced appreciably, and the resistance to incubation and osmotic lysis be strengthened. This fact provides a new approach to study the mcehanism of hemolysis, and also suggests a possibility of the usage of ODP-choline in blood preservation.更多还原