【摘要】 用负离子络合型催化剂——Al/Zn双金属氧桥烷氧化物,[（RO）₂OAlO]₂Zn,研究了ε-己内酯与D,L-丙交酯的嵌段共聚合,合成了预定结构的单分散的（?/?1.12）AB型嵌段共聚物,通过控制两种链段的比例能有效控制药物释放和生物降解的速度,可望成为新型生物降解性控制药物释放的载体及其它生物医用材料。更多还原

【Abstract】 The "living" sequential block copolymerization of e-caprolactone (CL) and DL-lactide(LA) by bimetallic UUUUUUUU-oxobutoxide has been investigated and the well defined AB type block copolymers with narrow molecular weight distribution (Mw/Mn 1.1) and microphase separation motphology were synthesized In vitro, the complete degradation time of the block copolymer films in deionized water at 50℃ ranging from several months to 3 years depending on the molar ratio of CL/LA, in it. In vitro the matrix release rate of norgestrel varies with the ratio of CL/LA.更多还原