【摘要】 本文报告了近交系C57BL、ICR、615和津白Ⅰ小鼠以及昆明杂交系小鼠感染大陆品系日本血吸虫后体内虫体发育的生物学,包括各品系小鼠体内的虫负荷、两性虫体的体长、性腺及出现虫卵前期等病原生物学的基础资料。更多还原

【Abstract】 A study was carried out to evaluate the development of Schistosoma japonicum (Chinese (mainland) strain) in inbred and outbred mice. Male mice of four inbred strains (C57BL, ICR, 615, Jin-Bai I ) and two outbred strains (Km-P, Km-S) were used. Cercariae were collected from many F1 laboratory-bred and -infected Oncomelania hupensis hupensis. Both snails and schistosomes were originated from Anwei Province. Each mouse was exposed to 40 cercariae of the same pool, 10 mice for each strain were used in each of the 10 experiments. Daily stool examination for schistosome eggs were started 33 days after infection, and after 6 weeks all mice were autopsied and their worm burden was recorded.Results obtained from the present study indicated that the six strains of mouse can be grouped into two categories based upon the worm burden. The first category included the C57BL, ICR and 615 inbred mire in which the worm burden was higher than that of the second category to which the inbred Jin-Bai I as well as outbred Km-P and Km-S strains belong. No consistent differences were observed in the body size or in the size of gonads of adult worms at the age of 42 days in the six strains of mice. But more hermaphroditic malformation of adult worms was found in outbred strain mice in which 11 specimens were observed than in inbred C57BL and ICR strains, in which only 2 and 1 specimens were obtained respectively. The mean prepatent period, namely the time elapsed between exposure of the host and the beginning of the appearance of eggs in the feces, varied with the strains of mice, from 35.5 +1.6 to 37.0 +1.8 days, with 615 strain mouse showing the longest,更多还原