【摘要】 本文分别利用摇瓶法和HPLC法测定了十七种α取代物和九种β取代物的脂水分配系数,并且用碎片加合法和π值加合法计算了这些化合物的脂水分配系数。讨论了这些化合物的logP的测定值与计算值之间的相关性。发现:HPLC的测定结果可以表示桂皮酰胺类化合物的相对大小;π值加合法能比碎片加合法更准确地估算桂皮酰胺类化合物的logP值。更多还原

【Abstract】 In this paper, the partition coefficients of 17 α-substituted compounds and 9 β-substituted compounds were masured by means of flask shaking or HPLC method, and were calculated by fragment method or π-method respectively. The correlation between measured values and calculated valeus for logP of cinnamamide compounds was discussed. It was found that the result obtained by means of HPLC might express relative magnitude of the partition coefficients of cinnamamide compounds and the π-method could estimate logP cinnamamide compounds more correctly than fragment method.更多还原