【摘要】 本实验采用氚标记的胸腺嘧啶核苷、氚标记的尿嘧啶核苷、氚标记的亮氨酸,观察人参地上部分总皂甙对标记前体参入骨髓细胞、肝细胞、肾细胞中DNA、RNA、蛋白质合成的影响,同时观察氚标记的亮氨酸参入血清蛋白的影响。结果表明,人参地上部分总皂甙连续给药一周70mg/k8和单次腹腔给药后4小时均能促进小白鼠骨髓细胞内DNA、RNA、蛋白质的合成。同样剂量连续给药一周也能促进血清蛋白质和肝脏、肾脏的RNA、蛋白质的合成,而对肝脏、肾脏DNA合成无明显影响。更多还原

【Abstract】 Effects of total saponin extracted from aerial parts of Ginseng on the biosynthesis of nucleic acids and protein were studied by radioisotope tracers.Results showed that the process of DNA,RNA, and protein synthesis in bone marrow cells of mice were promoted when total saponin was administered orally in the dose of 70mg/kg body weight every day for one week. The stimulating effects could be observed 4 hrs. after a single intraperitoneal injection. Total saponin stimulated the incorporation of labelled precursor(~3H-Leu) into mouse serum protein and could promote the process of RNA and protein synthesis in mouse liver and kidney, However, it did not show any influence on DNA synthesis when total saponin extracted from aerial parts of Ginseng was administered orally 70mg/kg body weight every day for one week.更多还原