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前列腺素E1对清除冠心病循环免疫复合物的研究
Effect of Prostaglandin E1 on the Elimination of Circulatory Immune Complex in Coronary Heart Disease
【摘要】 <正> 前列腺素是调节机体各种功能的重要生物活性物质。关于前列腺素E1(PGE1)有扩张血管、降低血压、抑制血小板聚集,抗组织胺、调节免疫等作用已有报道。但PGE1能否清除循环免疫复合物国内外尚未见有报导。近来临床应用PGE1缓解心绞痛与治疗心衰等获得令人鼓舞的效果。我们在应用PGE1治疗冠心病与心衰过程中发现PGE1有清除循环免疫复合物(CIC)现象,遂作了进一步的观察,并为研究冠心病的防治提供新的资料。现将其结果报导如下。
【Abstract】 For further observation of the action of PGE1 on eliminating CIC, we selected 48 patients with coronary heart disease whose CIC was positive by Clq binding test and polyethylene glycol precipitating method.In 10 cases of angina pectoris and 16 cases of myocardial infarction, PGE1 was given by intravenous drip,and subsequently CIC of all the patients became negative. However, in 10 cases of angina pectoris and 12 cases of myocardial infarction who were not treated with PGE1, their CIC remained positive. This demonstrated that PGE1 might have an effect on eliminating CIC. Furthermore, the detection of CIC was done every 5 days in 2 cases of angina pectoris and 3 cases of myocardial infarction without PGE1 treatment,showing that CIC could exist in the blood for 10 to 20 days or more.(p. 32)
- 【文献出处】 白求恩医科大学学报 , 编辑部邮箱 ,1983年04期
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