【摘要】 本文报导我们再次应用一次低剂量的二亚硝基哌嗪作为起动因子,用硫酸镍作为促动因子,进行诱发大鼠鼻咽癌的实验。将90只成年大鼠分为四组,即:二亚硝基哌嗪+镍胶组,二亚硝基哌嗪+镍水组,镍胶组和二亚硝基哌啼组。实验进行270天以后,将全部大鼠处死作病理检查。结果表明,在二亚硝基哌嗪+镍胶组的22只大鼠中,有5例发生恶性肿瘤(鼻咽原位鳞癌和早期鳞癌各1例,鼻腔未分化癌和鳞癌各1例,硬腭鳞癌1例),其它组则未见肿瘤发生。这再次表明,微量元素镍在诱发大鼠鼻咽癌中有促癌作用。 本实验还表明,肿瘤不仅发生在鼻咽,而且也发生在鼻腔和硬腭,因此,二亚硝基哌嗪不仅对鼻咽有亲合力,对鼻腔和硬腭也是有亲合力的。更多还原

【Abstract】 The dinitrosopiperazine (DNP) in its subthreshold dose was used as an initiator and Niso4 gel (Ni-gel) or Niso4 water solution (Ni-water) as a promotor in inducing NPC in rats. In the experiment four groups, namely, DNP + Ni-gel, DNP + Ni-water, Ni-gel and DNP, were designed. The results showed that five carcinomas were found in 22 rats of the DNP + Ni-gel experimental group and no carcinoma developed in the other three groups. This demonstrated that nickel sulfate may be recognised as a promotor in inducing NPC which had been reported previously by the authers themselves.Among the five carcinomas 2 occured in the nasopharynx (carcinoma in situ and early squamous cell carcinoma), 2 in the nasal cavity (undifferentiated carcinoma and squamous cell carcinoma) and 1 on the hard palate (Squamous cell carcimoma). It is worthwhile to point out that the carcinomas induced by the application of subthreshold dinitrosopiperazine and nickel sulfate developed not only in the nasopharynx but in the nasal cavity as well as hard palate also. This finding reveals that though the dinitrosopiperazine has the affinity to the nasopharynx for carcinogenesis, the nasal cavity and hard palate may alco be the sites to be affected.更多还原