【摘要】 <正> 膀胱癌是70年代上海市发病、死亡水平明显上升的恶性肿瘤之一,其与职业性染料接触关系密切。文献报道膀胱癌患者尿中β-葡萄糖醛酸酶(简称GRS)增高。本文研究并确定尿GRS的表示方法及其正常水平,提供肿瘤研究工作者在实践中探讨该更多还原

【Abstract】 A 3 hour urine specimen (from 6:00 a. m. to 9:00 a.m.) was collected from each ofthe 122 normal persons for the assay of urine β-glucuronidase (GRS). The activity of theenzyme expressed by GRS u/mg creatinine was found to be more reliable than those expres-sed as units in the whole specimen (GRS u/3hrs urine) or units per milliliter urine (GRSu/ml). Urine from 43 cases of bladder cancer were evaluated before operation, most ofthem showed increased GRS activity in the urine. Data collected suggest that for clinicaland practical use, the normal upper limit of GRS can be set at 8.5 u/mg creatinine for allages of males and females under 40 and 12 u/mg creatinine for females at or over 40. Thismethod was used as an auxiliary diagnostic criterion for the screening of occupational bladdercancers. The assay of urine GRS in 11 postoperative cases of bladder cancer revealed theactivity of the enzyme was significantly reduced in 8 cases.更多还原