【摘要】 <正> 黄曲霉毒素B₁(AFT_B1)通过肝微粒体酶系的羟基化作用,转化为毒性较低的M₁、Q₁,这是它代谢的主要途径之一。不同种属动物代谢模式和代谢速率的差异与其机体对黄曲霉毒素的敏感性有密切关系。 用人工污染黄曲霉毒素的饲料喂饲动物更多还原

【Abstract】 The report concerned with observations on aflatoxin B₁ （AFB₁） metabolism by human subjects after eating contaminated corn in hyperendemic areas of liver carcinoma, thatwas linear relationship between the amount of aflatoxin M₁（AFM₁） in the urine and thedose of the AFB₁ intake. It was estimated that in urine of 37 analytical periods of 24 hours and in single urine samples of 112 persons AFM₁ in the urine was found to be 1.31～1.49% of the amount of AFB₁ ingested. Except in one case, no uuchanged AFB₁ wasdetected in urine. The amount of AFM₁ in the urine of hepatifis B patients and HBsAgcarriers was 0.47% of that of the ingested AFB₁ while in the urine of healthy subjects it represented 4.81%. It suggested that the lower rate of AFM₁ excretion in hepatitis B patients and HBsAg carriers might be due to higher microsomal enzyme activity and changein the metabolic manner of AFB₁.更多还原