【摘要】 金钱草对小鼠淋巴组织有耗损作用,尤以胸腺的变化最为明显,表现为髓质网状上皮细胞变性,哈氏小体消失,皮质变薄,胸腺细胞锐减;脾和淋巴结中T细胞分布区域的细胞成分显著减少。文中讨论了金钱草的免疫抑制作用的机理。更多还原

【Abstract】 Our earlier work showed that Lysima chia christinae Hance suppressed the immune responses both cellularly and Immorally. Meanwhile, it was shown to enhance the phagocytic activities of macrophages and neu-trophile granulocytes.An apparent depletion in thymus,spleen and mesenteric lymph nodes of mice was detected after an oral dose of Chinese herb Lysimachia hem-sleyana Maxim. Histologically, the thymus displayed significant changes including degeneration of reticuloepithelium, disappearance of Hassall’s corpuscles and marked progressive lymphoid depletion. The cellular elements in the paracortical areas of mesenteric lymph nodes were scanty. In the spleen, the periarteriolar lymphoid sheaths were markedly reduced. Neonatal mice from pregnant mice administered with the herb showed thymic dysplasia and did not recover completely until 15 days after birth. Results suggested that thymus is the target organ of the action of the herb. The changes occurred in lymph nodes and spleen are probably secondary as a result of interference with T-cell maturation. The mechanism of its im-munosuppressive effect and precautions in its clinical use were discussed.更多还原