【摘要】 用肝脏血管造型和病理组织学方法观察吡喹酮对家兔日本血吸虫病肝硬化的影响。感染尾蚴后18周,用吡喹酮100mg/kg/日进行两天治疗,所有治愈家兔肝脏血管模型、病理形态及组织学的异常变化均在停药后20～36周得到很好恢复,提示吡喹酮是一个治愈血吸虫病肝硬化较为理想的药物。更多还原

【Abstract】 An evaluation of praziquantel on rabbit liver cirrhosis due to schistoso-miasis according to pathological changes was reported. Rabbits were treated 18 weeks after infection with praziquantel 100mg/kg/day for 2 days. All cured rabbits showed an excellent recovery 20-36 weeks after treatment with favorable pathological changes: i.e. ,(1)disappearance of vasodilatation, with decrease of hepatic arterioles and increase of portal branches; (2) disappearance of black-brown color, nodular appearance and hard feeling; and (3) disappearance of ova in portal areas, surrounded by collagen fibers and newly delevoped arterioles. Results indicated that praziquantel was a drug of choice in treatment for liver cirrhosis due to schistosomiasis.( Acknowledgmemt of support from the UNDP/World Bank/WHO Special Program for Research and Training in Tropical Diseases )更多还原