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变叶裸实中抗癌成分美登素、美登普林及其他成分的分离和鉴定

ISOLATION AND IDENTIFICATION OF ANTITUMOR PRINCIPLE MAYTANSINE,MAYTANPRINE AND OTHER CONSTITUENTS FROM GYMNOSPORIA DIVERSIFOLIA

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【作者】 何直昇周韵丽马广恩徐任生何其敏

【Author】 He Zhi-sheng ZHou Yun-li Ma Guang-en Xu Ren-sheng (Shanghai Institute of Materia Medica,Academia sinica)He Qi-min (South China Institute of Botany,Academia Sinica)

【机构】 中国科学院上海药物研究所中国科学院上海药物研究所中国科学院华南植物研究所

【摘要】 结合应用简便的干柱层析,低压柱层析等技术,从变叶裸实中成功地分到了抗癌活性成分美登素和美登普林,分离步骤较已报道的方法简便。还分离出卫矛醇,木栓酮,β-香树脂醇,β-谷甾醇和山萘甙,山萘酚-7-氧-鼠李糖甙。

【Abstract】 The potential antitumor principles,maytansine and maytanprine were isolated from the overground parts of Gymnosporia diversifolia for the first time.The method of separation was modified by application of dry column chromatography,low pressure column chromatography and other separation techniques.Besides,six known com- pounds were also isolated and identificated as dulcitol,friedelin,β-amyrin,β-sitosterol, kaempferitrin and kaempferol-7-O-rhamnoside respectively.The latter two flavonoids were not reported in this genus before.

  • 【文献出处】 Journal of Integrative Plant Biology ,植物学报(英文版) , 编辑部邮箱 ,1982年04期
  • 【被引频次】12
  • 【下载频次】101
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