【摘要】 从景德镇链霉菌的发酵液中分离获得的抗生素14A,红外光谱、核磁共振谱、质谱及其他理化数据表明是一个蒽环类抗生素。它对噬菌体SP₁0、HeLa肿瘤细胞株有强抑制作用,并对革兰氏阳性细菌有抗菌作用,体内肿瘤模型筛选结果表明抗生素14A对小白鼠艾氏腹水癌有效。更多还原

【Abstract】 From the fermentation broth of theStreptomyces jindetsensis, an antibioticcomponent designated 14 A was isolated.UV, IR, NMR and MS spectra as wellas chemical and biological properties pinpo-inted to the anthracycline group. It posses-ses strong action on phage SP-10, Hela cellsand a moderate antitumor activity on E.C.cells in vivo. LD60 is about 45.5mg/kg i.v.更多还原