【摘要】 以克山病病区和非病区粮饲养大鼠（饲料号为13和35）6—13周进行⁷⁵Se示踪代谢实验,观察11种组织脏器（褐脂、胸腺、血液、心脏、肺、肌肉、骨、肾、脾、肝、肠）⁷⁵Se（Na₂SeO₃）的吸收量和体内分布状况。结果表明,自由进食条件下,病区饲料组动物⁷⁵Se吸收量高于非病饲料组。其中以13号莜麦饲料组差异最为明显（A实验）。对饲条件下病区组动物⁷⁵Se的吸收量仍高于非病区组。但是差异程度较自由进食组为小（B实验）。各组动物体内不同组织脏器⁷⁵Se的分布梯度呈现一定规律性。皆以肾脏的吸收量为最高,其次是肝、脾脏及胸腺等,吸收量最低的是肌肉、心脏及骨骼。 在观察的一周之内,随时间的增加,⁷⁵Se于组织脏器中的含量,病区饲料组与非病区饲料组有不同的动态变化。 病区与非病区组间⁷⁵Se吸收量规律性差别,反映了病区组动物在病区出产的饲料影响下,体内硒不足或缺乏,表明病区与非病区出产的粮食存在着质的差异,证实了病区水土——食物链因素对动物机体硒代谢有明显影响。更多还原

【Abstract】 Observations were conducted on 11 kinds of tissues and organs(brown adipose tissue, thymus gland, blood, heart, lungs, muscle, bone, kidneys, spleen, liver, and intestine) in experimental animals, which were fed on crops from endemic areas of Keshan disease and non-endemic areas for 8-13 weeks. The absorption and distribution of 75Se (Na2 SeO3) in above tissue and organs were studied. Results revealed that the absorption of Na2-SeO3 in experimental group fed on crops from endemic area was higher than control group fed on crops from non-endemic area. The gradient of distribution of 75Se in various organs was regular: The highest absorption was in kidneys, the lesser was in liver, spleen and thyrnus, the least was in muscle, heart and bones.In one week observation, the contents of 75Se changed as time passed, but the fluctuating changes of the two groups were different.The regular differences of 75Se absorption as above, revealed a distinction between endemic and non-endemic crops. Under the influences of the crops on experimental animals, there appeared more or less a condition of selenium deficiency, which proved that the soil-water-food chain had apparently influenced the selenium metabolism of the organisms.更多还原