【摘要】 <正> 近年来,不少研究工作都涉及镁与心脏的联系,诸如镁与缺血性心脏病的关系,镁与心力衰竭、镁与心律失常、镁与洋地黄中毒等均有阐述。有人推测缺镁可能会产生显著的心肌功能改变,并可能通过钾缺乏,而较快破坏心肌细胞的完整性。一些材料表明心肌细胞线粒体与肝细胞线粒体相比,前者对镁的亲和力大,含镁量也多,所以心肌细胞对镁的缺更多还原

【Abstract】 This paper reports briefly the results on research about magnesium in relation to etiology of Keshan Disease.According to the water analysis, the magnesium contents in endemic districts are low. These characteristics are consistent with the low magnesium levels in the blood, hair, and urine of the local inhabitants and the vegetables and staple grains in endemic areas.In the magnesium treated group of 447 Keshan Disease patients, the effective rate was 71.6% as shown by ECG changes. In animal experiments, one group of rats was fed on cereals, water and vegetables from endemic areas for three months, and 6% of the animals in this group showed myocardial lesion. The pathological changes and distribution were similar to Keshan Disease. Magnesium supplementation was effective in preventing such changes. The magnesium contents of the skeletal muscle of rats in this group sometimes were lower than those led on foods irom non-endemic districts, hut the magnesium contents of myocardia and their mitochondria, whole blood and hair of rats were not different statistically (p>0.05).According to the water analysis for magnesium, the therapeutic trials with magnesium salts and the animal experiments, we suppose that there might be some myocardial necrotizing factors in magnesium deficiency in endemic districts.更多还原