【摘要】 本实验初步分析了7903抗小鼠MES的作用机制。这种作用可能与其影响脑内5-HT的代谢有关;因为7903使脑内5-HT含量升高的时间变化规律与其抗小鼠MES效应的时间规律有密切的相关性。此外,用利血平降低脑内单胺类介质时,可使7903抗MES作用明显减弱。单独使用PCPA减少脑内5-HT含量时,也减弱7903的抗MES作用。相反,给利血平化的小鼠单独补充5-HT前体L-色氨酸,提高脑内5-HT含量则可加强7903的抗MES作用。可见,7903的抗MES作用与5-HT的功能有关。更多还原

【Abstract】 The mechanism of anticonvulsant action of 7903 was studied. It may be related to serotoninergic system. 7903 was found to be able to increase the concentration of 5-HT and 5-HIAA in mice brain. The peak time of such action was at the first hour after treatment and gradually returned to normal level within 12 hours. This change of 5-HT was closely related to its anticonvulsant action, the correlation coefficent was 0.93 (P<0.001). Results of other experiments further support this finding. Reserpine was shown to antagonize the anticonvulsant action of 7903. Reserpinized mice were pretreated with L-tryptophane, the precursor of 5-HT, to supplement the concentration of depleted 5-HT (nearly to 80%).In such a condition, the anticonvulsant action of 7903 was recovered. In contrast, normal mice pretreated with PCPA to block the synthesis of 5-HT, decreased the anticonvulsant action of 7903.The concentration of NE was slightly decreased at the first hour after treatment with 7903, then gradually increased, and reached a peak on the 12th hours after treatment. At this time, the anticonvulsant action of the drug completely disappeared. The concentration of DA did not change within the 12-hour period.更多还原